KARELA 60 CAPS – BITTER MELONBitter Melon (Karela) contains four very promising bioactive compounds. These compounds activate a protein called AMPK, which is well known for regulating fuel metabolism and enabling glucose uptake, processes which are impaired in diabetics. Bitter Melon (Karela) contains a lectin that has insulin-like activity. The insulin-like bioactivity of this lectin is due to its linking together 2 insulin receptors. This lectin lowers blood glucose concentrations by acting on peripheral tissues and, similar to insulin’s effects in the brain, suppressing appetite. This lectin is likely a major contributor to the hypoglycemic effect that develops after eating Bitter Melon (Karela) and why it may be a way of managing adult-onset diabetes. Lectin binding is non-protein specific, and this is likely why Bitter Melon (Karela) has been credited with immunostimulatory activity – by linking receptors that modulate the immune system, thereby stimulating said receptors.Indication : Helps control blood sugar level. Dosage: Take 1 capsule twice daily, preferably before meals or as recommended by the Physician. It should ideally be taken on empty stomach. For better results it should be taken with warm water. Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the physician. References: J. Med Food. 2012 Feb; 15(2):101-7. doi: 10.1089/jmf.2010.0258. Epub 2011 Dec 22. Antidiabetic potentials of Momordica charantia: multiple mechanisms behind the effects. Chaturvedi Phytomedicine 2011 Dec 15; 19(1):32-7. doi: 10.1016/j.phymed.2011.06.019. Epub 2011 Nov 30. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Keller AC, MA J, KAvalier A, He K, Brillantes AM, Kennely EJ.Indian J Biochem Biophys 2010 Aug; 47(4):227-33.Anti-hyperglycemic and anti-oxidative effect of aqueous extract of Momordica charantia pulp and Trigonella foenum graecum seed in alloxan-induced diabetic rats. Tripathy UN, Chandra D.Oxid Med Cell Longev 2009 Nov-Dec; 2(5):290-6. doi: 10.4161/oxim.2.5.9529.The plant extracts of Momordica charantia and Trigonella foenum-graecum have anti-oxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus. Tripathy UN, Chandra D J Nutr 2010 Dec; 104(11):1613-20. doi: 10.1017/S0007114510002680. Epub 2010 Jul 9.Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice. Colman SD, Mueller AS, Palau J, Krawinkel MB.Appl Biochem Biotechnol 2010 Apr; 160(8):2388-400. doi: 10.1007/s12010-009-8799-1. Epub 2009 Nov 11.Complementary and comparative study on hypoglycemic and antihyperglycemic activity of various extracts of Eugenia jambolana seed, Momordica charantia fruits, Gymnema sylvestre, and Trigonella foenum graecum seeds in rats. Yadav M, Lavania A, Tomar R, Prasad GB, Jain S, Yadav H.


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